Santa Fe Island, also called Barrington Island after British Admiral Samuel Barrington, is a small, relatively flat island at the center of the Archipelago, to the southeast of Santa Cruz Island. Geologically, it is one of the oldest volcanoes, with rock formations below the surface of the water that date back 3.9 million years. There is strong evidence that giant tortoises were once native to Santa Fe.
Santa Fe is home to two species endemic to the island: the Santa Fe Land Iguana (Conolophus pallidus) and the Santa Fe Rice Rat (Oryzomys bauri). The land iguana population was recently estimated to have 6,500-7,000 individuals.